Achilles Tendon by Andrej Čretnik

By Andrej Čretnik

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2010). Components of the transforming growth factor-beta family and the pathogenesis of human Achilles tendon pathology--a genetic association study. Rheumatology (Oxford) 49: 2090-2097. , & Postacchini, F. (1976). A classification of Achilles tendon disease. The American Journal of Sports Medicine, 4(4), 145–150. Raleigh SM, van der Merwe L, Ribbans WJ, Smith RK, Schwellnus MP, and Collins M. (2009). Variants within the MMP3 gene are associated with Achilles tendinopathy: possible interaction with the COL5A1 gene.

Medicine Sport Science, 54: 176186, 2009. Williams FM, Popham M, Hart DJ, de Schepper E, Bierma-Zeinstra S, Hofman A, Uitterlinden AG, Arden NK, Cooper C, Spector TD, Valdes AM, and van Meurs J. (2011). GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women. Arthritis and rheumatism, 63: 708712. Young JS, Kumta SM, and Maffulli N. (2005) Achilles tendon rupture and tendinopathy: management of complications. Foot and ankle clinics, 10: 371-382.

Finally the ‘less flexible’ COL5A1 TT genotype has been shown to be significantly associated with improved endurance running performance (Posthumus et al, 2011; Brown et al, 2011b). This finding is in agreement with the published inverse relationship between musculotendineous stiffness and running economy (Arampatzis et al, 2006; Dumke et al, 2010; Fletcher et al, 2010). As reviewed above the COL5A1 rs12722 SNP has been associated with Achilles tendinopathy and other exercise-related phenotypes.

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