Advances in Pharmacological Research and Practice. by J. Knoll and K. Kelemen (Eds.)

By J. Knoll and K. Kelemen (Eds.)

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Extra info for Advances in Pharmacological Research and Practice. Proceedings of the 4th Congress of the Hungarian Pharmacological Society, Budapest, 1985, 1st Edition

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Heart and Vessels 1:29-35. R. , 1978, Effects of nifedipine on myocardial perfusion and ischemic injury in dogs. Res. 43:372-380. , Takeda,K. , 1984, Anti-arrhythmic effects of (-)-camitine chloride and its acetyl analogue on canine late ventricular arrhythmia induced by ligation of the coronary artery as related to improvement of mitochondrial function. Pharmacol. 82:533-542. , Ishii,M. , 1985, Antiarrhythmic effects of coronary vasodilators on canine ventricular arrhythmia models. Pharmacol. 38:73-82.

Lipocortin injected subcutaneously into carotid ar­ tery ligated rats exerted no cerebroprotective effect, showing that it does not pass the blood brain barrier. These results suggest that the cardioprotective and cerebroprotective effect of glucocorticoids may be mediated via the formation and re­ lease of lipocortin-like substances. Introduction It is now generally accepted that mediators of acute in­ flammation, especially of eicosanoids, are greatly involved in ischaemic disorders of the myocardium and brain.

These are /a/ residual infarct size /Yusuf and Sleight 1983/; /b/ left ventricular hypertrophy /Kannel and Thomas 1982/; and /c/ abnormalities of wall motion /Califf et al. 1978/. /, given within 6 hours of AMI, and followed by 100 mg daily for 10 days, caused a 30% reduction in infarct size, as measured by reduction in cumulative creatine Phospho­ kinase /CPK/ and R wave score on the ECG. 1985/. In this study, there was a highly significant reduction in cardio­ vascular deaths in the 0-1 day period /116 v.

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